Welcome to the Home Page of

Dr. N. Jayaraman

Associate Professor

Department of Organic Chemistry

Tel.: 091 80 2293-2578 (office); 2293-2406 (lab)

Fax: 091 80 2360-0529

E-mail: jayaraman@orgchem.iisc.ernet.in

Education:

• Ph.D.: Indian Institute of Technology, Kanpur (1988 - 1994) (Supervisor: Professor S. Ranganathan)
• Postdoctoral Fellow: University of Birmingham, England (1994 - 1997) and University of California, Los Angeles, USA (1997 - 1999) (Mentor: Professor J.F. Stoddart)

Major research projects of the group concern with (a) carbohydrate chemistry and (b) dendrimer chemistry. Synthesis and studies are the main focus in these areas. In relevance to the advancements in the above major research areas, the following specific themes have been undertaken in the group.

(i) Carbohydrates synthesis and structural studies

(ii) Studies of carbohydrate-protein interactions and the role of multivalency

(iii) Materials properties of carbohydrates

(iv) Synthesis of new dendrimers

(v) Chemical, biological and materials studies of dendrimers.

Please click on the major topics to view details of research in the above two major areas.

Representative Publications

• Dendrimers as photochemical reaction media. Photochemical behavior of unimolecular and bimolecular reactions in water-soluble dendrimers, Kaanumalle, L. S.; Ramesh, R.; Murthy Maddipatla, V. S. N.; Nithyanandhan, J.; Jayaraman, N.; Ramamurthy, V. J. Org. Chem. 2005, 70, 5062-5069.

• Photoswitchable cluster glycosides as tools to probe carbohydrate-protein interactions: Synthesis and lectin binding studies of azobenzene containing multivalent sugar ligands, Srinivas, O.; Mitra, N.; Surolia, A.; Jayaraman, N. Glycobiology 2005, 15, 861-873.

• Observation of chiral smectic phase (SmC*) in azobenzene linked bolaamphiphiles containing free sugars Abraham, S.; Paul, S.; Narayan, G.; Prasad, S. K.; Shankar Rao, D. S.; Jayaraman, N.; Das, S. Adv. Funct. Mater. 2005, 15, 1579-1584.

• Synthesis and Langmuir studies of bivalent and monovalent a-D-mannopyranosides with Lectin Con A, Narasimha Murthy, B.; Sampath, S.; Jayaraman, N. Langmuir 2005, 21, 9591-9596.

• Synthesis and reactivity profiles of phosphinated poly(alkyl aryl ether) dendrimers, Nithyanandhan, J.; Jayaraman, N. Tetrahedron 2005, 61, 11184-11191.

• Synthesis and biological evaluation of mannose-6-phosphate coated multivalent dendritic cluster glycosides, Srinivas, O.; Radhika, S.; Bandaru, N. M.; Siva Kumar, N.; Jayaraman, N. Org. Biomol. Chem. 2005, 3, 4252-4257.

· Structure of poly(propyl ether imine) (PETIM) dendrimer from fully atomistic molecular dynamics simulation and by small angle X-ray scattering, Jana, C.; Jayamurugan, G.; Ganapathy, R.; Maiti, P. K.; Jayaraman, N.; Sood, A. K. J. Chem. Phys. 2006, In print.

· Efficient halogen-lithium exchange reactions to functionalize poly(alkyl aryl ether) dendrimers, Nithyanandhan, J.; Jayaraman, N. Tetrahedron 2006, 62, In print.